The Biomedical Imaging Center (BIC) at Rensselaer Polytechnic Institute (RPI) is a transdisciplinary team working on x-ray computed tomography, optical molecular tomography, and other unconventional methods with collaborators of unique caliber and insight. We target innovative and influential ideas and results via world-class partnerships; balance theoretical, algorithmic, systematic, and practical aspects; and train imaging “scieneers“/educators for the future. To continue RPI’s glorious tradition and address major healthcare challenges, we welcome your advice and collaboration at ge-wang@ieee.org or intesx@rpi.edu.